Adrenal Stress Profile

The salivary Adrenal Stress Profile monitors the functioning of the adrenal glands’ cyclical release of cortisol and dehydroepiandrosterone (DHEA).

This profile measures the free (unbound) circulating portion of cortisol in multiple samplings over 24 hours following the circadian intervals expected for cortisol. Cortisol levels are elevated in the presence of chronic stress. DHEA is used by the body to produce androgens and estrogens.

The Adrenal Stress Profile is useful as a way to determine and monitor the functional pattern of cortisol before, during and after various therapies.

Prolonged stress responses can progress into dysfunctional hormonal patterns. Chronic stress can disrupt metabolism and ultimately contribute to neurological conditions, cardiovascular diseases, gastrointestinal symptoms, skin issues, and other complications. Signs or symptoms of prolonged stress or chronic metabolic dysfunction are indicators for adrenal testing.1,2

Who Should Test

  • neurological conditions such as chronic fatigue syndrome, mood disorders, depression, anxiety, memory loss

  • metabolic disorders such as menstrual irregularities, obesity, thyroid diseases

  • cardiovascular disease such as myocardial infarction

  • gastrointestinal disorders such as constipation, diarrhea, reflux

  • skin disorders such as eczematous dermatitis, psoriasis, decreased skin elasticity

  • inflammatory and immune dysfunction

Panel components

The adrenal stress profile includes six saliva collection vials. While only five collections are required, an optional sixth collection is recommended for deeper insights into your hormone function. There are five to six cortisol collections and one DHEA-S collection.

Benefits of testing

Since stress and inflammation are major underlying factors in many chronic diseases, checking levels of both cortisol and DHEA can be a window into how well the body is managing this critical factor of chronic illness.

Both cortisol and DHEA, produced by the adrenal glands, affect carbohydrate, lipid and protein metabolism, as well as thyroid hormone and sex hormone function.


Adrenal Stress Profile-$155.00

When purchasing your test expect the following:

The kit will be shipped containing the necessary supplies within 3 business days. We will request a phlebotomist to contact you for scheduling of your blood draw at a time and location convenient for you.

Note: All blood draw services are handled with accredited and licensed 3rd party companies. We are not responsible for scheduling, drawing, handling or shipment back to the Cell Science laboratory.

For information on having your test kit mailed to you, email