MethylDetox Profile

The Methyl Detox Profile tests critical genes in the methylation pathway. The methylation pathway is the major part of detoxification and the metabolic cycle. More than 50% of people are affected by genetic variations in the methylation pathway.1-3 This profile enables you to intelligently use nutritional supplementation based on your genetics. The Methyl Detox Profile gives comprehensive insights into the functional status of 3 major genes associated with the methionine/homocysteine cycle.

Methyl Detox Profile SampleWho may benefit from this test?

  • Cardiovascular Diseases such as hypertension, coronary artery disease, stroke 4-10

  • Neurological Disorders such as depression, dementia, Alzheimer’s disease, ADD/ADHD, autism spectrum disorder, chronic fatigue syndrome, migraine, insomnia 7, 10-17

  •  Metabolic Conditions such as metabolic syndrome, diabetes, kidney diseases, reduced ability to metabolize medications, multiple chemical sensitivity 10, 18-21

  • Musculoskeletal Disorders such as osteoporosis (in patients with Parkinson’s disease) 10, 22

  • Eye Diseases such as macular degeneration 23, 24

  • Cancer such as colorectal, breast 1, 10, 25

Pricing & Contents

Advanced MethylDetox Profile-$350.00 (does not include blood draw fee)*blood test only

MTHFR, MTR, MTRR, COMT, AHCY, Homocysteine

Basic MethylDetox Profile-$250.00 (does not include blood draw fee/saliva test optional)

MTHFR, MTR, COMT, Homocysteine 

Advanced MethylDetox Profile/ Genetic Only-$300.00 (does not include blood draw fee/saliva test optional)


Basic MethylDetox Profile/ Genetic Only-$200.00 (does not include blood draw fee/saliva test optional)


Individual Genes-$110.00 (does not include blood draw fee/saliva test optional)



Test Components


The MTHFR gene’s purpose is to produce
the important MTHFR enzyme in the body.
This enzyme is an important part of maintaining optimal health. If the MTHFR gene has a mutation, folate metabolism can be negatively impacted. Improper folate metabolism is implicated in many different diseases. 5, 6, 10, 26-29

2. MTR

MTR codes for the enzyme, methionine synthase (MS). MS converts homocysteine to methionine using methylated vitamin B12. Mutations in this gene significantly impact homocysteine metabolism, which can increase the risk

for a number of chronic conditions such
as cardiovascular diseases, metabolic and neurological conditions and certain cancers. 30


The MTRR gene codes for the important enzyme, methionine synthase reductase (MSR).
Methionine synthase reductase is required for the proper function of methionine synthase (see MTR). Both genes act together to convert homocysteine to methionine. Mutations can be involved with

the development of cancers, Parkinson’s disease, depression, hypertension and many others .31-36


COMT is the major gene involved in methylation. It plays an important role in a variety of disorders, including estrogen-induced cancers, Parkinson’s disease, depression, hypertension and many others. COMT is also necessary for maintaining the proper balance of neurotransmitters with SAMe obtained
from methionine. Genetic mutations in COMT can result in various neurological problems
and has also been associated with Autism. 31-36


AHCY is the only enzyme known to convert S-Adenosylhomocysteine (AdoHcy) to homocysteine. It is crucial that AHCY immediately converts AdoHcy to homocysteine and adenine in order to maintain optimal methylation potential. Studies show a

link between mutations in this gene with poor methylation potential and severe myopathies, developmental delays and hypermethioninemia.

6. Homocysteine

Homocysteine is an amino acid that is involved in maintaining the methionine cycle. Elevated homocysteine levels are well-known risk factors for chronic disease, particularly cardiovascular, diabetes and neurodegenerative disorders. 7, 10, 37

When purchasing your test expect the following:

The kit will be shipped containing the necessary supplies within 3 business days. We will request a phlebotomist to contact you for scheduling of your blood draw at a time and location convenient for you.

Note: All blood draw services are handled with accredited and licensed 3rd party companies. We are not responsible for scheduling, drawing, handling or shipment back to the Cell Science laboratory.

For information on having your test kit mailed to you, email

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